CovidFranceV1, Main, Exploration, bibRecord, 000331

Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19: Experience From Paris.

Identifieur interne : 000331 ( Main/Exploration ); précédent : 000330; suivant : 000332

Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19: Experience From Paris.

Auteurs : Simon Escalard [France] ; Benjamin Maïer [France] ; Hocine Redjem [France] ; François Delvoye [France] ; Solène Hébert [France] ; Stanislas Smajda [France] ; Gabriele Ciccio [France] ; Jean-Philippe Desilles [France] ; Mikael Mazighi [France] ; Raphael Blanc [France] ; Michel Piotin [France]

Source :

Stroke [ 1524-4628 ] ; 2020.

RBID : pubmed:32466736

Descripteurs français

English descriptors

KwdEn :
- Aged (MeSH), Arterial Occlusive Diseases (complications), Arterial Occlusive Diseases (diagnostic imaging), Blood Coagulation Disorders (etiology), Brain (diagnostic imaging), Brain Ischemia (diagnostic imaging), Brain Ischemia (etiology), Brain Ischemia (therapy), Cerebral Arteries (MeSH), Cerebral Veins (MeSH), Coronavirus Infections (complications), Female (MeSH), Hospital Mortality (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Plasminogen Activators (therapeutic use), Pneumonia, Viral (complications), Stroke (diagnostic imaging), Stroke (etiology), Stroke (therapy), Thrombectomy (MeSH), Thrombolytic Therapy (MeSH), Time-to-Treatment (MeSH), Tissue Plasminogen Activator (therapeutic use), Treatment Outcome (MeSH).
MESH :
- chemical , therapeutic use : Plasminogen Activators, Tissue Plasminogen Activator.
- complications : Arterial Occlusive Diseases, Coronavirus Infections, Pneumonia, Viral.
- diagnostic imaging : Arterial Occlusive Diseases, Brain, Brain Ischemia, Stroke.
- etiology : Blood Coagulation Disorders, Brain Ischemia, Stroke.
- therapy : Brain Ischemia, Stroke.
- Aged, Cerebral Arteries, Cerebral Veins, Female, Hospital Mortality, Humans, Male, Middle Aged, Pandemics, Thrombectomy, Thrombolytic Therapy, Time-to-Treatment, Treatment Outcome.

Abstract

BACKGROUND AND PURPOSE

Higher rates of strokes have been observed in patients with coronavirus disease 2019 (COVID-19), but data regarding the outcomes of COVID-19 patients suffering from acute ischemic stroke due to large vessel occlusion (LVO) are lacking. We report our initial experience in the treatment of acute ischemic stroke with LVO in patients with COVID-19.

METHODS

All consecutive patients with COVID-19 with acute ischemic stroke due to LVO treated in our institution during the 6 first weeks of the COVID-19 outbreak were included. Baseline clinical and radiological findings, treatment, and short-term outcomes are reported.

RESULTS

We identified 10 patients with confirmed COVID-19 treated for an acute ischemic stroke due to LVO. Eight were men, with a median age of 59.5 years. Seven had none or mild symptoms of COVID-19 at stroke onset. Median time from COVID-19 symptoms to stroke onset was 6 days. All patients had brain imaging within 3 hours from symptoms onset. Five patients had multi-territory LVO. Five received intravenous alteplase. All patients had mechanical thrombectomy. Nine patients achieved successful recanalization (mTICI2B-3), none experienced early neurological improvement, 4 had early cerebral reocclusion, and a total of 6 patients (60%) died in the hospital.

CONCLUSIONS

Best medical care including early intravenous thrombolysis, and successful and prompt recanalization achieved with mechanical thrombectomy, resulted in poor outcomes in patients with COVID-19. Although our results require further confirmation, a different pharmacological approach (antiplatelet or other) should be investigated to take in account inflammatory and coagulation disorders associated with COVID-19.

DOI: 10.1161/STROKEAHA.120.030574
PubMed: 32466736
PubMed Central: PMC7282400

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001072
to stream Main, to step Curation: 001072

Le document en format XML

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<country xml:lang="fr">France</country>
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<country xml:lang="fr">France</country>
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<country xml:lang="fr">France</country>
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<country xml:lang="fr">France</country>
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<country xml:lang="fr">France</country>
<wicri:regionArea>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
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<author><name sortKey="Ciccio, Gabriele" sort="Ciccio, Gabriele" uniqKey="Ciccio G" first="Gabriele" last="Ciccio">Gabriele Ciccio</name>
<affiliation wicri:level="3"><nlm:affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Desilles, Jean Philippe" sort="Desilles, Jean Philippe" uniqKey="Desilles J" first="Jean-Philippe" last="Desilles">Jean-Philippe Desilles</name>
<affiliation wicri:level="3"><nlm:affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazighi, Mikael" sort="Mazighi, Mikael" uniqKey="Mazighi M" first="Mikael" last="Mazighi">Mikael Mazighi</name>
<affiliation wicri:level="3"><nlm:affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blanc, Raphael" sort="Blanc, Raphael" uniqKey="Blanc R" first="Raphael" last="Blanc">Raphael Blanc</name>
<affiliation wicri:level="3"><nlm:affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Piotin, Michel" sort="Piotin, Michel" uniqKey="Piotin M" first="Michel" last="Piotin">Michel Piotin</name>
<affiliation wicri:level="3"><nlm:affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
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<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Arterial Occlusive Diseases (complications)</term>
<term>Arterial Occlusive Diseases (diagnostic imaging)</term>
<term>Blood Coagulation Disorders (etiology)</term>
<term>Brain (diagnostic imaging)</term>
<term>Brain Ischemia (diagnostic imaging)</term>
<term>Brain Ischemia (etiology)</term>
<term>Brain Ischemia (therapy)</term>
<term>Cerebral Arteries (MeSH)</term>
<term>Cerebral Veins (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Female (MeSH)</term>
<term>Hospital Mortality (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Plasminogen Activators (therapeutic use)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Stroke (diagnostic imaging)</term>
<term>Stroke (etiology)</term>
<term>Stroke (therapy)</term>
<term>Thrombectomy (MeSH)</term>
<term>Thrombolytic Therapy (MeSH)</term>
<term>Time-to-Treatment (MeSH)</term>
<term>Tissue Plasminogen Activator (therapeutic use)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (imagerie diagnostique)</term>
<term>Accident vasculaire cérébral (thérapie)</term>
<term>Accident vasculaire cérébral (étiologie)</term>
<term>Activateur tissulaire du plasminogène (usage thérapeutique)</term>
<term>Activateurs du plasminogène (usage thérapeutique)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Artères cérébrales (MeSH)</term>
<term>Artériopathies oblitérantes (complications)</term>
<term>Artériopathies oblitérantes (imagerie diagnostique)</term>
<term>Délai jusqu'au traitement (MeSH)</term>
<term>Encéphale (imagerie diagnostique)</term>
<term>Encéphalopathie ischémique (imagerie diagnostique)</term>
<term>Encéphalopathie ischémique (thérapie)</term>
<term>Encéphalopathie ischémique (étiologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (complications)</term>
<term>Mortalité hospitalière (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Thrombectomie (MeSH)</term>
<term>Traitement thrombolytique (MeSH)</term>
<term>Troubles de l'hémostase et de la coagulation (étiologie)</term>
<term>Veines de l'encéphale (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Plasminogen Activators</term>
<term>Tissue Plasminogen Activator</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Arterial Occlusive Diseases</term>
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Arterial Occlusive Diseases</term>
<term>Brain</term>
<term>Brain Ischemia</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Blood Coagulation Disorders</term>
<term>Brain Ischemia</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Accident vasculaire cérébral</term>
<term>Artériopathies oblitérantes</term>
<term>Encéphale</term>
<term>Encéphalopathie ischémique</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Brain Ischemia</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Accident vasculaire cérébral</term>
<term>Encéphalopathie ischémique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term>
<term>Activateurs du plasminogène</term>
<term>Artériopathies oblitérantes</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term>
<term>Encéphalopathie ischémique</term>
<term>Troubles de l'hémostase et de la coagulation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cerebral Arteries</term>
<term>Cerebral Veins</term>
<term>Female</term>
<term>Hospital Mortality</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Thrombectomy</term>
<term>Thrombolytic Therapy</term>
<term>Time-to-Treatment</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Artères cérébrales</term>
<term>Délai jusqu'au traitement</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mortalité hospitalière</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Thrombectomie</term>
<term>Traitement thrombolytique</term>
<term>Veines de l'encéphale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND AND PURPOSE</b>
</p>
<p>Higher rates of strokes have been observed in patients with coronavirus disease 2019 (COVID-19), but data regarding the outcomes of COVID-19 patients suffering from acute ischemic stroke due to large vessel occlusion (LVO) are lacking. We report our initial experience in the treatment of acute ischemic stroke with LVO in patients with COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>All consecutive patients with COVID-19 with acute ischemic stroke due to LVO treated in our institution during the 6 first weeks of the COVID-19 outbreak were included. Baseline clinical and radiological findings, treatment, and short-term outcomes are reported.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>We identified 10 patients with confirmed COVID-19 treated for an acute ischemic stroke due to LVO. Eight were men, with a median age of 59.5 years. Seven had none or mild symptoms of COVID-19 at stroke onset. Median time from COVID-19 symptoms to stroke onset was 6 days. All patients had brain imaging within 3 hours from symptoms onset. Five patients had multi-territory LVO. Five received intravenous alteplase. All patients had mechanical thrombectomy. Nine patients achieved successful recanalization (mTICI2B-3), none experienced early neurological improvement, 4 had early cerebral reocclusion, and a total of 6 patients (60%) died in the hospital.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Best medical care including early intravenous thrombolysis, and successful and prompt recanalization achieved with mechanical thrombectomy, resulted in poor outcomes in patients with COVID-19. Although our results require further confirmation, a different pharmacological approach (antiplatelet or other) should be investigated to take in account inflammatory and coagulation disorders associated with COVID-19.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32466736</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>08</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4628</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>51</Volume>
<Issue>8</Issue>
<PubDate><Year>2020</Year>
<Month>08</Month>
</PubDate>
</JournalIssue>
<Title>Stroke</Title>
<ISOAbbreviation>Stroke</ISOAbbreviation>
</Journal>
<ArticleTitle>Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19: Experience From Paris.</ArticleTitle>
<Pagination><MedlinePgn>2540-2543</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/STROKEAHA.120.030574</ELocationID>
<Abstract><AbstractText Label="BACKGROUND AND PURPOSE">Higher rates of strokes have been observed in patients with coronavirus disease 2019 (COVID-19), but data regarding the outcomes of COVID-19 patients suffering from acute ischemic stroke due to large vessel occlusion (LVO) are lacking. We report our initial experience in the treatment of acute ischemic stroke with LVO in patients with COVID-19.</AbstractText>
<AbstractText Label="METHODS">All consecutive patients with COVID-19 with acute ischemic stroke due to LVO treated in our institution during the 6 first weeks of the COVID-19 outbreak were included. Baseline clinical and radiological findings, treatment, and short-term outcomes are reported.</AbstractText>
<AbstractText Label="RESULTS">We identified 10 patients with confirmed COVID-19 treated for an acute ischemic stroke due to LVO. Eight were men, with a median age of 59.5 years. Seven had none or mild symptoms of COVID-19 at stroke onset. Median time from COVID-19 symptoms to stroke onset was 6 days. All patients had brain imaging within 3 hours from symptoms onset. Five patients had multi-territory LVO. Five received intravenous alteplase. All patients had mechanical thrombectomy. Nine patients achieved successful recanalization (mTICI2B-3), none experienced early neurological improvement, 4 had early cerebral reocclusion, and a total of 6 patients (60%) died in the hospital.</AbstractText>
<AbstractText Label="CONCLUSIONS">Best medical care including early intravenous thrombolysis, and successful and prompt recanalization achieved with mechanical thrombectomy, resulted in poor outcomes in patients with COVID-19. Although our results require further confirmation, a different pharmacological approach (antiplatelet or other) should be investigated to take in account inflammatory and coagulation disorders associated with COVID-19.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Escalard</LastName>
<ForeName>Simon</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Maïer</LastName>
<ForeName>Benjamin</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Redjem</LastName>
<ForeName>Hocine</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Delvoye</LastName>
<ForeName>François</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hébert</LastName>
<ForeName>Solène</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smajda</LastName>
<ForeName>Stanislas</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ciccio</LastName>
<ForeName>Gabriele</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Desilles</LastName>
<ForeName>Jean-Philippe</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mazighi</LastName>
<ForeName>Mikael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blanc</LastName>
<ForeName>Raphael</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Piotin</LastName>
<ForeName>Michel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>05</Month>
<Day>29</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Stroke</MedlineTA>
<NlmUniqueID>0235266</NlmUniqueID>
<ISSNLinking>0039-2499</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>EC 3.4.21.-</RegistryNumber>
<NameOfSubstance UI="D010960">Plasminogen Activators</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.21.68</RegistryNumber>
<NameOfSubstance UI="D010959">Tissue Plasminogen Activator</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001157" MajorTopicYN="N">Arterial Occlusive Diseases</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001778" MajorTopicYN="N">Blood Coagulation Disorders</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002545" MajorTopicYN="N">Brain Ischemia</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002536" MajorTopicYN="N">Cerebral Arteries</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002550" MajorTopicYN="N">Cerebral Veins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010960" MajorTopicYN="N">Plasminogen Activators</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017131" MajorTopicYN="N">Thrombectomy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015912" MajorTopicYN="N">Thrombolytic Therapy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061665" MajorTopicYN="N">Time-to-Treatment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010959" MajorTopicYN="N">Tissue Plasminogen Activator</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">coagulation disorder</Keyword>
<Keyword MajorTopicYN="Y">outbreak</Keyword>
<Keyword MajorTopicYN="Y">stroke</Keyword>
<Keyword MajorTopicYN="Y">thrombectomy</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>5</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>8</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>5</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32466736</ArticleId>
<ArticleId IdType="doi">10.1161/STROKEAHA.120.030574</ArticleId>
<ArticleId IdType="pmc">PMC7282400</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Escalard, Simon" sort="Escalard, Simon" uniqKey="Escalard S" first="Simon" last="Escalard">Simon Escalard</name>
</region>
<name sortKey="Blanc, Raphael" sort="Blanc, Raphael" uniqKey="Blanc R" first="Raphael" last="Blanc">Raphael Blanc</name>
<name sortKey="Ciccio, Gabriele" sort="Ciccio, Gabriele" uniqKey="Ciccio G" first="Gabriele" last="Ciccio">Gabriele Ciccio</name>
<name sortKey="Delvoye, Francois" sort="Delvoye, Francois" uniqKey="Delvoye F" first="François" last="Delvoye">François Delvoye</name>
<name sortKey="Desilles, Jean Philippe" sort="Desilles, Jean Philippe" uniqKey="Desilles J" first="Jean-Philippe" last="Desilles">Jean-Philippe Desilles</name>
<name sortKey="Hebert, Solene" sort="Hebert, Solene" uniqKey="Hebert S" first="Solène" last="Hébert">Solène Hébert</name>
<name sortKey="Maier, Benjamin" sort="Maier, Benjamin" uniqKey="Maier B" first="Benjamin" last="Maïer">Benjamin Maïer</name>
<name sortKey="Mazighi, Mikael" sort="Mazighi, Mikael" uniqKey="Mazighi M" first="Mikael" last="Mazighi">Mikael Mazighi</name>
<name sortKey="Piotin, Michel" sort="Piotin, Michel" uniqKey="Piotin M" first="Michel" last="Piotin">Michel Piotin</name>
<name sortKey="Redjem, Hocine" sort="Redjem, Hocine" uniqKey="Redjem H" first="Hocine" last="Redjem">Hocine Redjem</name>
<name sortKey="Smajda, Stanislas" sort="Smajda, Stanislas" uniqKey="Smajda S" first="Stanislas" last="Smajda">Stanislas Smajda</name>
</country>
</tree>
</affiliations>
</record>

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Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19: Experience From Paris.

Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19: Experience From Paris.

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